Effect of pulmonary blood flow upon lung mechanics.

The Effect of Histamine on the Pulmonary Circulation in Man ¶

The influence of intra-alveolar pressure and respiratory mechanics on pulmonary hemodynamics has been extensively studied.' Rodbard has presented the view that bronchomotor tone is a prominent factor in the regulation of pulmonary blood flow,' but the effect of bronchoconstriction on pulmonary pressure and flow has, so far, been studied very little in humans.' If the pulmonary hypertension obse...

The effect of intermittent positive pressure breathing and voluntary hyperventilation upon the distribution of ventilation and pulmonary blood flow to the lung in chronic obstructive lung disease.

Effect of platelet-activating factor receptor antagonism on endotoxin-induced lung dysfunction in awake sheep.

To test the hypothesis that PAF partially mediates endotoxin-induced lung dysfunction, we studied the effects of two structurally dissimilar PAF receptor antagonists (SRI 63-441 and WEB 2086) on endotoxin-induced lung dysfunction in chronically instrumented awake sheep. Each animal was studied three times in varied order: infusion of endotoxin alone (Escherichia coli endotoxin 0.5 micrograms/kg...

Airway mechanics, gas exchange, and blood flow in a nonlinear model of the normal human lung.

A model integrating airway/lung mechanics, pulmonary blood flow, and gas exchange for a normal human subject executing the forced vital capacity (FVC) maneuver is presented. It requires as input the intrapleural pressure measured during the maneuver. Selected model-generated output variables are compared against measured data (flow at the mouth, change in lung volume, and expired O2 and CO2 con...

Impact of elevated pulmonary blood flow and capillary pressure on lung responsiveness.

Since alterations in pulmonary hemodynamics may lead to airway hyperreactivity, the consequences of individual changes in pulmonary blood flow (Qp) and capillary pressure (Pc) on lung responsiveness were investigated. During maintenance of a steady-state Pc of 5, 10, or 15 mmHg (groups 1-3), acute increases of Qp were generated in isolated, perfused rat lungs by simultaneous pulmonary arterial ...